The Immunological Challenge: Pre-existing Immunity
A significant hurdle for the Adeno-associated Virus Vector-based Gene Therapy Market is the issue of pre-existing immunity. AAV is a common, non-pathogenic virus that many people are exposed to naturally. As a result, a large percentage of the population has pre-existing neutralizing antibodies (NAbs) against specific AAV serotypes. When an AAV-based gene therapy is administered to a patient...
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